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Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block
[Image: see text] Many structurally and therapeutically diverse drugs interact with the human heart K(+) channel hERG by binding within the K(+) permeation pathway of the open channel, leading to drug-induced ‘long QT syndrome’. Drug binding to hERG is often stabilized by inactivation gating. In the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977586/ https://www.ncbi.nlm.nih.gov/pubmed/24471705 http://dx.doi.org/10.1021/ci400707h |