Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

ROCK1 and ROCK2 mediate important processes such as cell migration, invasion and metastasis; making them good targets for the development of antitumor agents. Recently, using a fragment-based approach and X-ray crystallography, we reported on the design and synthesis of novel Rho-kinase inhibitors (...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Ronil A., Liu, Yan, Wang, Binglin, Li, Rongshi, Sebti, Saïd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977753/
https://www.ncbi.nlm.nih.gov/pubmed/23396364
http://dx.doi.org/10.1038/onc.2012.634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977753/
https://www.ncbi.nlm.nih.gov/pubmed/23396364
http://dx.doi.org/10.1038/onc.2012.634

Ejemplares similares