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Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities

ROCK1 and ROCK2 mediate important processes such as cell migration, invasion and metastasis; making them good targets for the development of antitumor agents. Recently, using a fragment-based approach and X-ray crystallography, we reported on the design and synthesis of novel Rho-kinase inhibitors (...

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Detalles Bibliográficos
Autores principales:	Patel, Ronil A., Liu, Yan, Wang, Binglin, Li, Rongshi, Sebti, Saïd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977753/ https://www.ncbi.nlm.nih.gov/pubmed/23396364 http://dx.doi.org/10.1038/onc.2012.634

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