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Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

Multispecific proteins play a major role in controlling various functions such as signaling, regulation of transcription/translation, and immune response. Hence, a thorough understanding of the atomic-level principles governing multispecific interactions is important not only for the advancement of...

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Detalles Bibliográficos
Autores principales: Sharabi, Oz, Shirian, Jason, Grossman, Moran, Lebendiker, Mario, Sagi, Irit, Shifman, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977929/
https://www.ncbi.nlm.nih.gov/pubmed/24710006
http://dx.doi.org/10.1371/journal.pone.0093712