Gap-Directed Translesion DNA Synthesis of an Abasic Site on Circular DNA Templates by a Human Replication Complex

DNA polymerase ε (pol ε) is believed to be the leading strand replicase in eukaryotes whereas pols λ and β are thought to be mainly involved in re-synthesis steps of DNA repair. DNA elongation by the human pol ε is halted by an abasic site (apurinic/apyrimidinic (AP) site). We have previously report...

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Detalles Bibliográficos
Autores principales: Villani, Giuseppe, Shevelev, Igor, Orlando, Eleonora, Pospiech, Helmut, Syvaoja, Juhani E., Markkanen, Enni, Hubscher, Ulrich, Le Gac, Nicolas Tanguy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977967/
https://www.ncbi.nlm.nih.gov/pubmed/24710081
http://dx.doi.org/10.1371/journal.pone.0093908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977967/
https://www.ncbi.nlm.nih.gov/pubmed/24710081
http://dx.doi.org/10.1371/journal.pone.0093908

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