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Sensitizing the Therapeutic Efficacy of Taxol with Shikonin in Human Breast Cancer Cells
Shikonin, a small-molecule natural product which inhibits the activity of pyruvate kinase M2 (PKM2), has been studied as an anti-cancer drug candidate in human cancer models. Here, our results demonstrate that shikonin is able to sensitize human breast cancer cells to chemotherapy by paclitaxel (tax...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977981/ https://www.ncbi.nlm.nih.gov/pubmed/24710512 http://dx.doi.org/10.1371/journal.pone.0094079 |