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Motifs in the permeation pathway of connexin channels mediate voltage and Ca(2+) sensing

Connexin channels mediate electrical coupling, intercellular molecular signaling, and extracellular release of signaling molecules. Connexin proteins assemble intracellularly as hexamers to form plasma membrane hemichannels. The docking of two hemichannels in apposed cells forms a gap junction chann...

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Detalles Bibliográficos
Autores principales: Harris, Andrew L., Contreras, Jorge E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978323/
https://www.ncbi.nlm.nih.gov/pubmed/24744733
http://dx.doi.org/10.3389/fphys.2014.00113