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Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer’s disease
γ-Secretase-mediated production of amyloid β from the amyloid precursor protein is recognized as a central player in the neuropathogenesis of Alzheimer’s disease (AD). One of the most peculiar features of this enzymatic activity is the fact that it targets transmembrane domains of mostly type I inte...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978424/ https://www.ncbi.nlm.nih.gov/pubmed/24314151 http://dx.doi.org/10.1186/alzrt227 |