Cargando…

Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis

INTRODUCTION: Osteoarthritis (OA) is associated with the metabolic syndrome, however the underlying mechanisms remain unclear. We investigated whether low density lipoprotein (LDL) accumulation leads to increased LDL uptake by synovial macrophages and affects synovial activation, cartilage destructi...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Munter, Wouter, Blom, Arjen B, Helsen, Monique M, Walgreen, Birgitte, van der Kraan, Peter M, Joosten, Leo AB, van den Berg, Wim B, van Lent, Peter LEM
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978425/ https://www.ncbi.nlm.nih.gov/pubmed/24286458 http://dx.doi.org/10.1186/ar4367

Ejemplares similares

Early pain in females is linked to late pathological features in murine experimental osteoarthritis
por: Valdrighi, Natália, et al.
Publicado: (2023)

Nox2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis
por: Kruisbergen, Nik N. L., et al.
Publicado: (2021)

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis
por: Roeleveld, Debbie M., et al.
Publicado: (2017)

Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice
por: Aarts, Joyce, et al.
Publicado: (2020)

Mesenchymal stem cell therapy in osteoarthritis: advanced tissue repair or intervention with smouldering synovial activation?
por: van Lent, Peter LEM, et al.
Publicado: (2013)

Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis
por: Aarts, Joyce, et al.
Publicado: (2022)

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis
por: Rogier, Rebecca, et al.
Publicado: (2017)

Assessing the Accuracy of Estimated Lipoprotein(a) Cholesterol and Lipoprotein(a)‐Free Low‐Density Lipoprotein Cholesterol
por: Zheng, Weili, et al.
Publicado: (2022)

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation
por: Broeren, Mathijs G.A., et al.
Publicado: (2018)

Low‐Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events
por: Willeit, Peter, et al.
Publicado: (2020)

Innate Immunity and Sex: Distinct Inflammatory Profiles Associated with Murine Pain in Acute Synovitis
por: Valdrighi, Natália, et al.
Publicado: (2023)

Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study
por: de Molon, Rafael Scaf, et al.
Publicado: (2019)

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology
por: van Dalen, Stephanie C. M., et al.
Publicado: (2019)

IL-18 expression in synovial biopsies of patients with active rheumatoid arthritis is associated with enhanced levels of both IL-1 and TNFα
por: Joosten, LAB, et al.
Publicado: (2002)

Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients
por: Penumarthy, Swati, et al.
Publicado: (2013)

Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and total cholesterol/high-density lipoprotein cholesterol for the prediction of thin-cap fibroatheroma determined by intravascular optical coherence tomography
por: WANG, Yao, et al.
Publicado: (2020)

Total cholesterol/high-density lipoprotein cholesterol and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol as predictors of coronary artery calcification assessed by multidetector computed tomography coronary angiography
por: Elsadek Seaoud, Elshaimaa Aly M., et al.
Publicado: (2022)

Activation of circulating monocytes by low-density lipoprotein—a risk factor for osteoarthritis?
por: Kruisbergen, Nik N L, et al.
Publicado: (2022)

Triglycerides, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol in rats exposed to premium motor spirit fumes
por: Aberare, Ogbevire L., et al.
Publicado: (2011)

Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
por: Joosten, Leo AB, et al.
Publicado: (1999)

NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis
por: van Lent, Peter LEM, et al.
Publicado: (2005)

Association of the Low-density Lipoprotein Cholesterol/High-density Lipoprotein Cholesterol Ratio with Glecaprevir-pibrentasvir Treatment
por: Akutsu, Noriyuki, et al.
Publicado: (2021)

Inclisiran, Low-Density Lipoprotein Cholesterol and Lipoprotein (a)
por: Katsiki, Niki, et al.
Publicado: (2023)

Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
por: Davidson, Esmeralda N Blaney, et al.
Publicado: (2007)

Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
por: van Nieuwenhuijze, Annemarie E. M., et al.
Publicado: (2015)

Lipoproteins, cholesterol homeostasis and cardiac health
por: Daniels, Tyler F., et al.
Publicado: (2009)

New Perspectives on Cholesterol and Lipoprotein Metabolism
por: De Geest, Bart, et al.
Publicado: (2023)

Risk assessment of metabolic syndrome in adolescents using the triglyceride/high-density lipoprotein cholesterol ratio and the total cholesterol/high-density lipoprotein cholesterol ratio
por: Chu, Shou-Yu, et al.
Publicado: (2019)

Low‐Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific
por: Cupido, Arjen J., et al.
Publicado: (2022)

The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus
por: Hu, Xiangming, et al.
Publicado: (2022)

IL-1-driven cartilage and bone destruction are dependent on Toll-like receptor (TLR) 4, but not TLR2
por: Abdollahi-Roodsaz, S, et al.
Publicado: (2005)

Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
por: Joosten, LAB, et al.
Publicado: (2005)

Triglyceride to high-density lipoprotein cholesterol ratio and total cholesterol to high-density lipoprotein cholesterol ratio and risk of benign prostatic hyperplasia in Chinese male subjects
por: Zhu, Chen, et al.
Publicado: (2022)

Low-Density Lipoprotein Cholesterol Is Associated With Insulin Secretion
por: Dannecker, Corinna, et al.
Publicado: (2021)

Estimation of cardiovascular risk based on total cholesterol versus total cholesterol/high-density lipoprotein within different ethnic groups: The HELIUS study
por: Perini, Wilco, et al.
Publicado: (2019)

Low Density Lipoprotein-Cholesterol/High Density Lipoprotein-Cholesterol Ratio Predicts Plaque Vulnerability in Patients With Stable Angina
por: Kim, Jeong Hun, et al.
Publicado: (2012)

Non-high density lipoprotein cholesterol versus low density lipoprotein cholesterol as a discriminating factor for myocardial infarction
por: Sigdel, Manoj, et al.
Publicado: (2012)

Age and Cardiovascular Risk Attributable to Apolipoprotein B, Low‐Density Lipoprotein Cholesterol or Non‐High‐Density Lipoprotein Cholesterol
por: Sniderman, Allan D., et al.
Publicado: (2016)

Utility of Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio in Evaluating Incident Diabetes Risk
por: Sheng, Guotai, et al.
Publicado: (2022)

THE EFFECTS OF CHOLESTEROL DOSAGE, CORTISONE, AND DCA ON TOTAL SERUM CHOLESTEROL, LIPOPROTEINS, AND ATHEROSCLEROSIS IN THE RABBIT
por: Cook, Donald L., et al.
Publicado: (1952)

Cannot write session to /tmp/vufind_sessions/sess_5rmo6n8k0c8m47jdq2c4vo6916