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Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition
INTRODUCTION: Tau pathology is associated with a number of age-related neurodegenerative disorders. Few treatments have been demonstrated to diminish the impact of tau pathology in mouse models and none are yet effective in humans. Histone deacetylase 6 (HDAC6) is an enzyme that removes acetyl group...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978441/ https://www.ncbi.nlm.nih.gov/pubmed/24576665 http://dx.doi.org/10.1186/alzrt241 |