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Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

Microtubule-associated protein tau encoded by the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and function. Alternative splicing of MAPT pre-mRNA generates six major tau isoforms in the adult central nervous system resulting in tau proteins with three or four...

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Autores principales: Murray, Melissa E, Kouri, Naomi, Lin, Wen-Lang, Jack, Clifford R, Dickson, Dennis W, Vemuri, Prashanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978456/
https://www.ncbi.nlm.nih.gov/pubmed/24382028
http://dx.doi.org/10.1186/alzrt231
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author Murray, Melissa E
Kouri, Naomi
Lin, Wen-Lang
Jack, Clifford R
Dickson, Dennis W
Vemuri, Prashanthi
author_facet Murray, Melissa E
Kouri, Naomi
Lin, Wen-Lang
Jack, Clifford R
Dickson, Dennis W
Vemuri, Prashanthi
author_sort Murray, Melissa E
collection PubMed
description Microtubule-associated protein tau encoded by the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and function. Alternative splicing of MAPT pre-mRNA generates six major tau isoforms in the adult central nervous system resulting in tau proteins with three or four microtubule-binding repeat domains. In a group of neurodegenerative disorders called tauopathies, tau becomes aberrantly hyperphosphorylated and dissociates from microtubules, resulting in a progressive accumulation of intracellular tau aggregates. The spectrum of sporadic frontotemporal lobar degeneration associated with tau pathology includes progressive supranuclear palsy, corticobasal degeneration, and Pick’s disease. Alzheimer’s disease is considered the most prevalent tauopathy. This review is divided into two broad sections. In the first section we discuss the molecular classification of sporadic tauopathies, with a focus on describing clinicopathologic relationships. In the second section we discuss the neuroimaging methodologies that are available for measuring tau pathology (directly using tau positron emission tomography ligands) and tau-mediated neuronal injury (magnetic resonance imaging and fluorodeoxyglucose positron emission tomography). Both sections have detailed descriptions of the following neurodegenerative dementias – Alzheimer’s disease, progressive supranuclear palsy, corticobasal degeneration and Pick’s disease.
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spelling pubmed-39784562015-01-02 Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias Murray, Melissa E Kouri, Naomi Lin, Wen-Lang Jack, Clifford R Dickson, Dennis W Vemuri, Prashanthi Alzheimers Res Ther Review Microtubule-associated protein tau encoded by the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and function. Alternative splicing of MAPT pre-mRNA generates six major tau isoforms in the adult central nervous system resulting in tau proteins with three or four microtubule-binding repeat domains. In a group of neurodegenerative disorders called tauopathies, tau becomes aberrantly hyperphosphorylated and dissociates from microtubules, resulting in a progressive accumulation of intracellular tau aggregates. The spectrum of sporadic frontotemporal lobar degeneration associated with tau pathology includes progressive supranuclear palsy, corticobasal degeneration, and Pick’s disease. Alzheimer’s disease is considered the most prevalent tauopathy. This review is divided into two broad sections. In the first section we discuss the molecular classification of sporadic tauopathies, with a focus on describing clinicopathologic relationships. In the second section we discuss the neuroimaging methodologies that are available for measuring tau pathology (directly using tau positron emission tomography ligands) and tau-mediated neuronal injury (magnetic resonance imaging and fluorodeoxyglucose positron emission tomography). Both sections have detailed descriptions of the following neurodegenerative dementias – Alzheimer’s disease, progressive supranuclear palsy, corticobasal degeneration and Pick’s disease. BioMed Central 2014-01-02 /pmc/articles/PMC3978456/ /pubmed/24382028 http://dx.doi.org/10.1186/alzrt231 Text en Copyright © 2014 BioMed Central Ltd.
spellingShingle Review
Murray, Melissa E
Kouri, Naomi
Lin, Wen-Lang
Jack, Clifford R
Dickson, Dennis W
Vemuri, Prashanthi
Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
title Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
title_full Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
title_fullStr Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
title_full_unstemmed Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
title_short Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
title_sort clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978456/
https://www.ncbi.nlm.nih.gov/pubmed/24382028
http://dx.doi.org/10.1186/alzrt231
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