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Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the...

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Detalles Bibliográficos
Autores principales:	Badhan, Raj K. Singh, Chenel, Marylore, Penny, Jeffrey I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978528/ https://www.ncbi.nlm.nih.gov/pubmed/24647103 http://dx.doi.org/10.3390/pharmaceutics6010097

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