Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the...

Descripción completa

Detalles Bibliográficos
Autores principales: Badhan, Raj K. Singh, Chenel, Marylore, Penny, Jeffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978528/
https://www.ncbi.nlm.nih.gov/pubmed/24647103
http://dx.doi.org/10.3390/pharmaceutics6010097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978528/
https://www.ncbi.nlm.nih.gov/pubmed/24647103
http://dx.doi.org/10.3390/pharmaceutics6010097

Ejemplares similares