Development of a Region-Specific Physiologically Based Pharmacokinetic Brain Model to Assess Hippocampus and Frontal Cortex Pharmacokinetics

Central nervous system drug discovery and development is hindered by the impermeable nature of the blood–brain barrier. Pharmacokinetic modeling can provide a novel approach to estimate CNS drug exposure; however, existing models do not predict temporal drug concentrations in distinct brain regions....

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Detalles Bibliográficos
Autores principales: Zakaria, Zaril, Badhan, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874827/
https://www.ncbi.nlm.nih.gov/pubmed/29342085
http://dx.doi.org/10.3390/pharmaceutics10010014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874827/
https://www.ncbi.nlm.nih.gov/pubmed/29342085
http://dx.doi.org/10.3390/pharmaceutics10010014

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