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Application of Pharmacokinetic and Pharmacodynamic Analysis to the Development of Liposomal Formulations for Oncology

Liposomal formulations of anticancer agents have been developed to prolong drug circulating lifetime, enhance anti-tumor efficacy by increasing tumor drug deposition, and reduce drug toxicity by avoiding critical normal tissues. Despite the clinical approval of numerous liposome-based chemotherapeut...

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Detalles Bibliográficos
Autores principales: Ait-Oudhia, Sihem, Mager, Donald E., Straubinger, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978529/
https://www.ncbi.nlm.nih.gov/pubmed/24647104
http://dx.doi.org/10.3390/pharmaceutics6010137