Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malaria-infected mice at a single oral dose of only 8 mg/k...

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Detalles Bibliográficos
Autores principales: Woodard, Lauren E., Mott, Bryan T., Singhal, Vandana, Kumar, Nirbhay, Shapiro, Theresa A., Posner, Gary H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545/
https://www.ncbi.nlm.nih.gov/pubmed/27713236
http://dx.doi.org/10.3390/ph2030228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545/
https://www.ncbi.nlm.nih.gov/pubmed/27713236
http://dx.doi.org/10.3390/ph2030228

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