Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malaria-infected mice at a single oral dose of only 8 mg/k...

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Autores principales: Woodard, Lauren E., Mott, Bryan T., Singhal, Vandana, Kumar, Nirbhay, Shapiro, Theresa A., Posner, Gary H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545/
https://www.ncbi.nlm.nih.gov/pubmed/27713236
http://dx.doi.org/10.3390/ph2030228
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author Woodard, Lauren E.
Mott, Bryan T.
Singhal, Vandana
Kumar, Nirbhay
Shapiro, Theresa A.
Posner, Gary H.
author_facet Woodard, Lauren E.
Mott, Bryan T.
Singhal, Vandana
Kumar, Nirbhay
Shapiro, Theresa A.
Posner, Gary H.
author_sort Woodard, Lauren E.
collection PubMed
description Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malaria-infected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride.
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spelling pubmed-39785452014-04-10 Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine Woodard, Lauren E. Mott, Bryan T. Singhal, Vandana Kumar, Nirbhay Shapiro, Theresa A. Posner, Gary H. Pharmaceuticals (Basel) Article Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malaria-infected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride. Molecular Diversity Preservation International 2009-12-21 /pmc/articles/PMC3978545/ /pubmed/27713236 http://dx.doi.org/10.3390/ph2030228 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Woodard, Lauren E.
Mott, Bryan T.
Singhal, Vandana
Kumar, Nirbhay
Shapiro, Theresa A.
Posner, Gary H.
Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
title Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
title_full Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
title_fullStr Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
title_full_unstemmed Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
title_short Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine
title_sort malaria-infected mice are cured by a single low dose of a new silylamide trioxane plus mefloquine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978545/
https://www.ncbi.nlm.nih.gov/pubmed/27713236
http://dx.doi.org/10.3390/ph2030228
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