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PIK3CA mutations are frequently observed in BRCAX but not BRCA2 -associated male breast cancer

INTRODUCTION: Although a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown. We therefore examined the frequency and clinicopathological associations of the PIK3CA/mammalian target of rapamycin (mTOR) and mitogen-activated prote...

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Detalles Bibliográficos
Autores principales: Deb, Siddhartha, Do, Hongdo, Byrne, David, Jene, Nicholas, Dobrovic, Alexander, Fox, Stephen B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978692/
https://www.ncbi.nlm.nih.gov/pubmed/23971979
http://dx.doi.org/10.1186/bcr3463