Cargando…

PIK3CA mutations are frequently observed in BRCAX but not BRCA2 -associated male breast cancer

INTRODUCTION: Although a substantial proportion of male breast cancers (MBCs) are hereditary, the molecular pathways that are activated are unknown. We therefore examined the frequency and clinicopathological associations of the PIK3CA/mammalian target of rapamycin (mTOR) and mitogen-activated prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deb, Siddhartha, Do, Hongdo, Byrne, David, Jene, Nicholas, Dobrovic, Alexander, Fox, Stephen B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978692/ https://www.ncbi.nlm.nih.gov/pubmed/23971979 http://dx.doi.org/10.1186/bcr3463

Ejemplares similares

Enhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers
por: Yan, Max, et al.
Publicado: (2012)

Genotypic and phenotypic analysis of familial male breast cancer shows under representation of the HER2 and basal subtypes in BRCA-associated carcinomas
por: Deb, Siddhartha, et al.
Publicado: (2012)

BRCA2 carriers with male breast cancer show elevated tumour methylation
por: Deb, Siddhartha, et al.
Publicado: (2017)

Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies
por: Do, Hongdo, et al.
Publicado: (2009)

Genome-Wide Identification of BrCAX Genes and Functional Analysis of BrCAX1 Involved in Ca(2+) Transport and Ca(2+) Deficiency-Induced Tip-Burn in Chinese Cabbage (Brassica rapa L. ssp. pekinensis)
por: Cui, Shuning, et al.
Publicado: (2023)

Clinical management of women in BRCAX families: issues and controversies
por: Mitchell, G
Publicado: (2012)

PIK3CA Mutations Frequently Coexist with RAS and BRAF Mutations in Patients with Advanced Cancers
por: Janku, Filip, et al.
Publicado: (2011)

RAD21 overexpression is frequently observed in BRCA-X Prostate Cancers
por: Deb, S, et al.
Publicado: (2012)

BRCA1/2-negative, high-risk breast cancers (BRCAX) for Asian women: genetic susceptibility loci and their potential impacts
por: Lee, Joo-Yeon, et al.
Publicado: (2018)

Frequent PIK3CA mutations in eutopic endometrium of patients with ovarian clear cell carcinoma
por: Murakami, Kosuke, et al.
Publicado: (2021)

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant
por: Correia, Lizelle, et al.
Publicado: (2022)

High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies
por: Do, Hongdo, et al.
Publicado: (2008)

Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
por: Do, Hongdo, et al.
Publicado: (2008)

Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil-DNA glycosylase
por: Do, Hongdo, et al.
Publicado: (2012)

Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations
por: Deb, S, et al.
Publicado: (2014)

Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis
por: Takano, Elena A, et al.
Publicado: (2008)

Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations
por: Brouillard, Pascal, et al.
Publicado: (2021)

Somatic alterations of targetable oncogenes are frequently observed in BRCA1/2 mutation negative male breast cancers
por: Rizzolo, Piera, et al.
Publicado: (2016)

Mutations of PIK3CA in gastric adenocarcinoma
por: Li, Vivian Sze Wing, et al.
Publicado: (2005)

Mutations in PIK3CA are infrequent in neuroblastoma
por: Dam, Vincent, et al.
Publicado: (2006)

PIK3CA-mutations in breast cancer
por: Reinhardt, Kristin, et al.
Publicado: (2022)

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
por: Shi, Jing, et al.
Publicado: (2012)

High-Throughput Mutation Profiling of Primary and Metastatic Endometrial Cancers Identifies KRAS, FGFR2 and PIK3CA to Be Frequently Mutated
por: Krakstad, Camilla, et al.
Publicado: (2012)

Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection
por: Cacheux, Wulfran, et al.
Publicado: (2016)

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes
por: Hondow, Heather L, et al.
Publicado: (2011)

Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation
por: Sato, Seiya, et al.
Publicado: (2023)

Genetic alterations detected by comparative genomic hybridization in BRCAX breast and ovarian cancers of Brazilian population
por: Felicio, Paula Silva, et al.
Publicado: (2018)

PIK3CA mutation enrichment and quantitation from blood and tissue
por: Keraite, Ieva, et al.
Publicado: (2020)

Mutation of the PIK3CA oncogene in human cancers
por: Karakas, B, et al.
Publicado: (2006)

Initiating breast cancer by PIK3CA mutation
por: Miller, Todd W
Publicado: (2012)

PIK3CA Mutations in Hepatocellular Carcinoma in Korea
por: Kim, Heesue, et al.
Publicado: (2013)

PIK3CA Mutational Analysis of Parathyroid Adenomas
por: Riccardi, Aaliyah, et al.
Publicado: (2020)

Male BRCA mutation carriers: clinical characteristics and cancer spectrum
por: Ibrahim, Mohammed, et al.
Publicado: (2018)

PIK3CA and TP53 Gene Mutations in Human Breast Cancer Tumors Frequently Detected by Ion Torrent DNA Sequencing
por: Bai, Xusheng, et al.
Publicado: (2014)

PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome
por: Munari, Fernanda Franco, et al.
Publicado: (2018)

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma
por: Deshpande, Vikram, et al.
Publicado: (2011)

EGFR, PIK3CA, KRAS and BRAF mutations in meningiomas
por: BUJKO, MATEUSZ, et al.
Publicado: (2014)

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes
por: Janku, Filip, et al.
Publicado: (2012)

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
por: Madsen, Ralitsa R., et al.
Publicado: (2018)

PIK3CA mutation and colorectal cancer precision medicine
por: Hamada, Tsuyoshi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vqlpp2hh9ojt2brr9m20u334hu