Cargando…

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

Accumulation and aggregation of the microtubule-associated protein tau are a pathological hallmark of neurodegenerative disorders such as Alzheimer’s disease (AD). In AD, tau becomes abnormally phosphorylated and forms inclusions throughout the brain, starting in the entorhinal cortex and progressiv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978816/ https://www.ncbi.nlm.nih.gov/pubmed/24152385 http://dx.doi.org/10.1186/alzrt214

Ejemplares similares

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
por: Pooler, Amy M, et al.
Publicado: (2015)

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease
por: Pickett, Eleanor K., et al.
Publicado: (2017)

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics
por: Kent, Sarah A., et al.
Publicado: (2020)

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses
por: Rudinskiy, Nikita, et al.
Publicado: (2014)

Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model
por: Davies, Caitlin, et al.
Publicado: (2023)

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation
por: Nicholls, Samantha B., et al.
Publicado: (2017)

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain
por: Takeda, Shuko, et al.
Publicado: (2015)

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
por: Caballero, Benjamin, et al.
Publicado: (2021)

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy
por: Kopeikina, Katherine J., et al.
Publicado: (2013)

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease
por: Tai, Hwan-Ching, et al.
Publicado: (2014)

Alzheimer's disease: synapses gone cold
por: Koffie, Robert M, et al.
Publicado: (2011)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease
por: Jackson, Rosemary J., et al.
Publicado: (2016)

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
por: Lasagna-Reeves, Cristian A., et al.
Publicado: (2012)

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
por: Bryant, Annie G., et al.
Publicado: (2020)

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice
por: Fu, Hongjun, et al.
Publicado: (2016)

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
por: Kang, Seong Su, et al.
Publicado: (2020)

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
por: DeVos, Sarah L., et al.
Publicado: (2018)

Neuronal activity enhances tau propagation and tau pathology in vivo
por: Wu, Jessica W., et al.
Publicado: (2016)

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology
por: Yamada, Kaoru
Publicado: (2017)

Tau propagation is dependent on the genetic background of mouse strains
por: Dujardin, Simon, et al.
Publicado: (2022)

Experimental evidence for the age dependence of tau protein spread in the brain
por: Wegmann, Susanne, et al.
Publicado: (2019)

Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau
por: Dickson, John R, et al.
Publicado: (2021)

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
por: Fleeman, Rebecca M., et al.
Publicado: (2021)

Implication of tau propagation on neurodegeneration in Alzheimer’s disease
por: Lamontagne-Kam, Daniel, et al.
Publicado: (2023)

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
por: Hernández-Vega, Amayra, et al.
Publicado: (2017)

Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains
por: Welikovitch, Lindsay A., et al.
Publicado: (2023)

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation
por: Španić, Ena, et al.
Publicado: (2019)

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease
por: Lau, Dawn H. W., et al.
Publicado: (2016)

Alzheimer’s research—breakthrough or breakdown?
por: Spires-Jones, Tara L
Publicado: (2021)

Orchestrated experience-driven Arc/Arg3.1 responses are disrupted in a mouse model of Alzheimer’s disease
por: Rudinskiy, Nikita, et al.
Publicado: (2012)

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease
por: Kontsekova, Eva, et al.
Publicado: (2014)

Identification of disulfide cross-linked tau dimer responsible for tau propagation
por: Kim, Dohee, et al.
Publicado: (2015)

Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease
por: Schäfer, Amelie, et al.
Publicado: (2021)

A cell-based model of pathological tau uptake and propagation
por: Falcon, Ben, et al.
Publicado: (2013)

Spines, Plasticity, and Cognition in Alzheimer's Model Mice
por: Spires-Jones, Tara, et al.
Publicado: (2012)

Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases
por: Kamath, Tarun V, et al.
Publicado: (2021)

What is the evidence that tau pathology spreads through prion-like propagation?
por: Mudher, Amrit, et al.
Publicado: (2017)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
por: Arnsten, Amy F. T., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8mn21qkmoddto6bnjv1du0b0hl