Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials

INTRODUCTION: Oncostatin M (OSM) has been implicated in the pathophysiology of rheumatoid arthritis (RA) through its effect on inflammation and joint damage. GSK315234 is a humanised anti-OSM Immunoglobulin G1 (IgG1) monoclonal antibody (mAb). This 3-part study examines the safety, tolerability and...

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Detalles Bibliográficos
Autores principales: Choy, Ernest H, Bendit, Marina, McAleer, Dana, Liu, Feng, Feeney, Maria, Brett, Sara, Zamuner, Stefano, Campanile, Andrea, Toso, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978888/
https://www.ncbi.nlm.nih.gov/pubmed/24286335
http://dx.doi.org/10.1186/ar4312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978888/
https://www.ncbi.nlm.nih.gov/pubmed/24286335
http://dx.doi.org/10.1186/ar4312

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