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Autophagic/lysosomal dysfunction in Alzheimer’s disease

Autophagy serves as the sole catabolic mechanism for degrading organelles and protein aggregates. Increasing evidence implicates autophagic dysfunction in Alzheimer’s disease (AD) and other neurodegenerative diseases associated with protein misprocessing and accumulation. Under physiologic condition...

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Detalles Bibliográficos
Autores principales: Orr, Miranda E, Oddo, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979020/
https://www.ncbi.nlm.nih.gov/pubmed/24171818
http://dx.doi.org/10.1186/alzrt217