De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis

[Image: see text] The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitutio...

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Autores principales: Tatton, Matthew R., Simpson, Iain, Donohoe, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979090/
https://www.ncbi.nlm.nih.gov/pubmed/24646289
http://dx.doi.org/10.1021/ol500441q
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author Tatton, Matthew R.
Simpson, Iain
Donohoe, Timothy J.
author_facet Tatton, Matthew R.
Simpson, Iain
Donohoe, Timothy J.
author_sort Tatton, Matthew R.
collection PubMed
description [Image: see text] The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups.
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spelling pubmed-39790902014-04-08 De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis Tatton, Matthew R. Simpson, Iain Donohoe, Timothy J. Org Lett [Image: see text] The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups. American Chemical Society 2014-03-19 2014-04-04 /pmc/articles/PMC3979090/ /pubmed/24646289 http://dx.doi.org/10.1021/ol500441q Text en Copyright © 2014 American Chemical Society Terms of Use CC-BY (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html)
spellingShingle Tatton, Matthew R.
Simpson, Iain
Donohoe, Timothy J.
De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
title De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
title_full De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
title_fullStr De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
title_full_unstemmed De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
title_short De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis
title_sort de novo synthesis of multisubstituted aryl amines using alkene cross metathesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979090/
https://www.ncbi.nlm.nih.gov/pubmed/24646289
http://dx.doi.org/10.1021/ol500441q
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