A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis

INTRODUCTION: The aim of this study was to evaluate the safety, pharmacokinetics, and clinical response of brodalumab (AMG 827), a human, anti-IL-17 receptor A (IL-17RA) monoclonal antibody in subjects with moderate-to-severe rheumatoid arthritis (RA). METHODS: This phase Ib, randomized, placebo-con...

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Detalles Bibliográficos
Autores principales: Martin, David A, Churchill, Melvin, Flores-Suarez, Luis Felipe, Cardiel, Mario H, Wallace, Daniel, Martin, Richard, Phillips, Kristine, Kaine, Jeffrey L, Dong, Hua, Salinger, David, Stevens, Erin, Russell, Chris B, Chung, James B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979125/
https://www.ncbi.nlm.nih.gov/pubmed/24286136
http://dx.doi.org/10.1186/ar4347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979125/
https://www.ncbi.nlm.nih.gov/pubmed/24286136
http://dx.doi.org/10.1186/ar4347

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