ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS
Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979216/ https://www.ncbi.nlm.nih.gov/pubmed/24825994 |
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author | Elberry, Ahmed A. Harraz, Fathalla M. Ghareib, Salah A. Nagy, Ayman A. Gabr, Salah A. Suliaman, Mansour I. Abdel-Sattar, Essam |
author_facet | Elberry, Ahmed A. Harraz, Fathalla M. Ghareib, Salah A. Nagy, Ayman A. Gabr, Salah A. Suliaman, Mansour I. Abdel-Sattar, Essam |
author_sort | Elberry, Ahmed A. |
collection | PubMed |
description | Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities of the both extracts against carbon tetrachloride (CCl(4))-induced hepatic damage in rats. Both extracts were given orally in a dose of 500 mg/kg/day for 4 weeks along with CCl(4) started at the 7th week of induction of hepatotoxicity. The antihepatotoxic activity was assessed by measuring aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH), tissue content and malondialdehyde (MDA) as well as histopathological examination. Both extracts showed a significant antihepatotoxic effect by reducing significantly the levels of AST, ALT and LDH. However, ALP levels were decreased non-significantly. Regarding the antioxidant activity, they exhibited significant effects by increasing the GPx, GR and GST activities with increased GSH tissue contents and decreased production of MDA level. Furthermore, both extracts alleviated histopathological changes in rats’ liver treated with CCl(4). M. vulgare and W. somnifera protect the rats’ liver against CCl(4)-induced hepatotoxicity. This effect may be attributed, at least in part, to the antioxidant activities of these extracts. |
format | Online Article Text |
id | pubmed-3979216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39792162014-05-13 ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS Elberry, Ahmed A. Harraz, Fathalla M. Ghareib, Salah A. Nagy, Ayman A. Gabr, Salah A. Suliaman, Mansour I. Abdel-Sattar, Essam J Basic Clin Pharm Original Article Marrubium vulgare and Withania somnifera are used in folk medicine of several countries. Many researches showed that they are used for the treatment of variety of diseases due to their antioxidant effects. The present aim of this study was to evaluate the antihepatotoxic and antioxidant activities of the both extracts against carbon tetrachloride (CCl(4))-induced hepatic damage in rats. Both extracts were given orally in a dose of 500 mg/kg/day for 4 weeks along with CCl(4) started at the 7th week of induction of hepatotoxicity. The antihepatotoxic activity was assessed by measuring aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), reduced glutathione (GSH), tissue content and malondialdehyde (MDA) as well as histopathological examination. Both extracts showed a significant antihepatotoxic effect by reducing significantly the levels of AST, ALT and LDH. However, ALP levels were decreased non-significantly. Regarding the antioxidant activity, they exhibited significant effects by increasing the GPx, GR and GST activities with increased GSH tissue contents and decreased production of MDA level. Furthermore, both extracts alleviated histopathological changes in rats’ liver treated with CCl(4). M. vulgare and W. somnifera protect the rats’ liver against CCl(4)-induced hepatotoxicity. This effect may be attributed, at least in part, to the antioxidant activities of these extracts. Medknow Publications & Media Pvt Ltd 2010-09 2010-11-15 /pmc/articles/PMC3979216/ /pubmed/24825994 Text en Copyright: © Journal of Basic and Clinical Pharmacy http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Elberry, Ahmed A. Harraz, Fathalla M. Ghareib, Salah A. Nagy, Ayman A. Gabr, Salah A. Suliaman, Mansour I. Abdel-Sattar, Essam ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS |
title | ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS |
title_full | ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS |
title_fullStr | ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS |
title_full_unstemmed | ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS |
title_short | ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS |
title_sort | antihepatotoxic effect of marrubium vulgare and withania somnifera extracts on carbon tetrachloride-induced hepatotoxicity in rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979216/ https://www.ncbi.nlm.nih.gov/pubmed/24825994 |
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