The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity

Accurate DNA synthesis in vivo depends on the ability of DNA polymerases to select dNTPs from a nucleotide pool dominated by NTPs. High fidelity replicative polymerases have evolved to efficiently exclude NTPs while copying long stretches of undamaged DNA. However, to bypass DNA damage, cells utiliz...

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Detalles Bibliográficos
Autores principales: Donigan, Katherine A., McLenigan, Mary P., Yang, Wei, Goodman, Myron F., Woodgate, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979402/
https://www.ncbi.nlm.nih.gov/pubmed/24532793
http://dx.doi.org/10.1074/jbc.M113.545442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979402/
https://www.ncbi.nlm.nih.gov/pubmed/24532793
http://dx.doi.org/10.1074/jbc.M113.545442

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