The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

Glucocorticoids (GC) regulate cell fate and immune function. We identified the metastasis-promoting methyltransferase, metastasis-related methyltransferase 1 (WBSCR22/Merm1) as a novel glucocorticoid receptor (GR) regulator relevant to human disease. Merm1 binds the GR co-activator GRIP1 but not GR....

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Detalles Bibliográficos
Autores principales: Jangani, Maryam, Poolman, Toryn M., Matthews, Laura, Yang, Nan, Farrow, Stuart N., Berry, Andrew, Hanley, Neil, Williamson, Andrew J. K., Whetton, Anthony D., Donn, Rachelle, Ray, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Gene Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979408/
https://www.ncbi.nlm.nih.gov/pubmed/24488492
http://dx.doi.org/10.1074/jbc.M113.540906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979408/
https://www.ncbi.nlm.nih.gov/pubmed/24488492
http://dx.doi.org/10.1074/jbc.M113.540906

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