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Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures
Advances in sequencing have enabled the identification of mutations acquired by bacterial pathogens during infection(1-10). However, it remains unclear whether adaptive mutations fix in the population or lead to pathogen diversification within the patient(11,12). Here, we study the genotypic diversi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979468/ https://www.ncbi.nlm.nih.gov/pubmed/24316980 http://dx.doi.org/10.1038/ng.2848 |