Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation

Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrP(Sc) can trigger pathogenic events. How levels of PrP are regulated is poor...

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Detalles Bibliográficos
Autores principales: Shao, Jia, Choe, Vitnary, Cheng, Haili, Tsai, Yien Che, Weissman, Allan M., Luo, Shiwen, Rao, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979651/
https://www.ncbi.nlm.nih.gov/pubmed/24714645
http://dx.doi.org/10.1371/journal.pone.0092290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979651/
https://www.ncbi.nlm.nih.gov/pubmed/24714645
http://dx.doi.org/10.1371/journal.pone.0092290

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