MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses

Because multiple myeloma (MM) cells are at risk for endoplasmic reticulum (ER) stress, they require a carefully regulated mechanism to promote protein translation of selected transcripts when proliferation is stimulated. MAPK-interacting kinases (MNKs) may provide this mechanism by enhancing cap-dep...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Yijiang, Frost, Patrick, Hoang, Bao, Yang, Yonghui, Bardeleben, Carolyne, Gera, Joseph, Lichtenstein, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979714/
https://www.ncbi.nlm.nih.gov/pubmed/24714040
http://dx.doi.org/10.1371/journal.pone.0094011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979714/
https://www.ncbi.nlm.nih.gov/pubmed/24714040
http://dx.doi.org/10.1371/journal.pone.0094011

Ejemplares similares