A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

Neuromodulators have profound effects on behavior, but the dynamics of their intracellular effectors has remained unclear. Most neuromodulators exert their function via G-protein-coupled receptors (GPCRs). One major challenge for understanding neuromodulator action is the lack of dynamic readouts of...

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Detalles Bibliográficos
Autores principales: Chen, Yao, Saulnier, Jessica L., Yellen, Gary, Sabatini, Bernardo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980114/
https://www.ncbi.nlm.nih.gov/pubmed/24765076
http://dx.doi.org/10.3389/fphar.2014.00056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980114/
https://www.ncbi.nlm.nih.gov/pubmed/24765076
http://dx.doi.org/10.3389/fphar.2014.00056

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