STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

Signal transducer and activator of transcription 3 (STAT3) is a potent regulator of gliomagenesis through its induction of angiogenesis, host immunosuppression, and tumor invasion. Gain of function mutations result in constitutive activation of STAT3 in glioma cells, making STAT3 an attractive targe...

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Detalles Bibliográficos
Autores principales: Kim, Jennifer E., Patel, Mira, Ruzevick, Jacob, Jackson, Christopher M., Lim, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980601/
https://www.ncbi.nlm.nih.gov/pubmed/24518612
http://dx.doi.org/10.3390/cancers6010376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980601/
https://www.ncbi.nlm.nih.gov/pubmed/24518612
http://dx.doi.org/10.3390/cancers6010376

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