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Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tu...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980612/ https://www.ncbi.nlm.nih.gov/pubmed/24549119 http://dx.doi.org/10.3390/cancers6010416 |
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author | Pahwa, Sonia Stawikowski, Maciej J. Fields, Gregg B. |
author_facet | Pahwa, Sonia Stawikowski, Maciej J. Fields, Gregg B. |
author_sort | Pahwa, Sonia |
collection | PubMed |
description | Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors. |
format | Online Article Text |
id | pubmed-3980612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-39806122014-04-09 Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression Pahwa, Sonia Stawikowski, Maciej J. Fields, Gregg B. Cancers (Basel) Review Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors. MDPI 2014-02-17 /pmc/articles/PMC3980612/ /pubmed/24549119 http://dx.doi.org/10.3390/cancers6010416 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Pahwa, Sonia Stawikowski, Maciej J. Fields, Gregg B. Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
title | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
title_full | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
title_fullStr | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
title_full_unstemmed | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
title_short | Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression |
title_sort | monitoring and inhibiting mt1-mmp during cancer initiation and progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980612/ https://www.ncbi.nlm.nih.gov/pubmed/24549119 http://dx.doi.org/10.3390/cancers6010416 |
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