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Nitric oxide regulates cardiac intracellular Na(+) and Ca(2 +) by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism()
In the heart, Na/K-ATPase regulates intracellular Na(+) and Ca(2 +) (via NCX), thereby preventing Na(+) and Ca(2 +) overload and arrhythmias. Here, we test the hypothesis that nitric oxide (NO) regulates cardiac intracellular Na(+) and Ca(2 +) and investigate mechanisms and physiological consequence...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981027/ https://www.ncbi.nlm.nih.gov/pubmed/23612119 http://dx.doi.org/10.1016/j.yjmcc.2013.04.013 |