Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer

Human DNA polymerase (pol) β is essential for base excision repair. We previously reported a triple somatic mutant of pol β (p.P261L/T292A/I298T) found in an early onset prostate tumor. This mutation abolishes polymerase activity, and the wild-type allele was not present in the tumor, indicating a c...

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Detalles Bibliográficos
Autores principales: AN, CHANGLONG, BEARD, WILLIAM A., CHEN, DESHENG, WILSON, SAMUEL H., MAKRIDAKIS, NICK M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981039/
https://www.ncbi.nlm.nih.gov/pubmed/23877444
http://dx.doi.org/10.3892/ijo.2013.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981039/
https://www.ncbi.nlm.nih.gov/pubmed/23877444
http://dx.doi.org/10.3892/ijo.2013.2022

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