Cargando…

Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer

Human DNA polymerase (pol) β is essential for base excision repair. We previously reported a triple somatic mutant of pol β (p.P261L/T292A/I298T) found in an early onset prostate tumor. This mutation abolishes polymerase activity, and the wild-type allele was not present in the tumor, indicating a c...

Descripción completa

Detalles Bibliográficos
Autores principales:	AN, CHANGLONG, BEARD, WILLIAM A., CHEN, DESHENG, WILSON, SAMUEL H., MAKRIDAKIS, NICK M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981039/ https://www.ncbi.nlm.nih.gov/pubmed/23877444 http://dx.doi.org/10.3892/ijo.2013.2022

Ejemplares similares

Structure and Mechanism of DNA Polymerase β
por: Beard, William A., et al.
Publicado: (2014)

Translesion DNA Polymerases and Cancer
por: Makridakis, Nick M., et al.
Publicado: (2012)

DNA Polymerase β Gap-Filling Translesion DNA Synthesis
por: Chary, Parvathi, et al.
Publicado: (2012)

Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate
por: Perera, Lalith, et al.
Publicado: (2020)

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction
por: Shock, David D., et al.
Publicado: (2017)

Revealing the role of the product metal in DNA polymerase β catalysis
por: Perera, Lalith, et al.
Publicado: (2017)

The K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER
por: Wang, Yuanyuan, et al.
Publicado: (2015)

Watching a DNA polymerase in action
por: Freudenthal, Bret D, et al.
Publicado: (2014)

Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients
por: Ali, Bassam R., et al.
Publicado: (2010)

BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients
por: Sugawara, Tatsuo, et al.
Publicado: (2016)

Transitions in DNA polymerase β μs-ms dynamics related to substrate binding and catalysis
por: DeRose, Eugene F, et al.
Publicado: (2018)

Substrate Rescue of DNA Polymerase β Containing a Catastrophic L22P Mutation
por: Kirby, Thomas W., et al.
Publicado: (2014)

In silico modeling of the pore region of a KCNQ4 missense mutant from a patient with hearing loss
por: Namba, Kazunori, et al.
Publicado: (2012)

Heterozygous FMN2 missense variant found in a family case of premature ovarian insufficiency
por: Li, Jie, et al.
Publicado: (2022)

Exon Skipping in a Dysf-Missense Mutant Mouse Model
por: Malcher, Jakub, et al.
Publicado: (2018)

Functional Relevance of Missense Mutations Affecting the N-Terminal Part of Shank3 Found in Autistic Patients
por: Hassani Nia, Fatemeh, et al.
Publicado: (2018)

Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity
por: Yupanqui-Lozno, Hernan, et al.
Publicado: (2019)

Understanding protein structural changes for oncogenic missense variants
por: Hernandez, Rolando, et al.
Publicado: (2021)

Editorial: Structural understanding of the functional consequences of missense mutation
por: Tian, Jian, et al.
Publicado: (2023)

Transition State in DNA Polymerase β Catalysis: Rate-Limiting Chemistry Altered by Base-Pair Configuration
por: Oertell, Keriann, et al.
Publicado: (2014)

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening
por: Kim, Taejin, et al.
Publicado: (2016)

PCR-free method detects high frequency of genomic instability in prostate cancer
por: Makridakis, Nick M., et al.
Publicado: (2009)

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion
por: Freudenthal, Bret D., et al.
Publicado: (2013)

Structural Insights into Phosphorylation-Mediated Polymerase Function Loss for DNA Polymerase β Bound to Gapped DNA
por: Srivastava, Amit, et al.
Publicado: (2023)

Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide
por: Freudenthal, Bret D., et al.
Publicado: (2014)

Proteins Found in the Triple-Negative Breast Cancer Secretome and Their Therapeutic Potential
por: McHenry, Peter R., et al.
Publicado: (2023)

Oncogenic mechanisms of HOXB13 missense mutations in prostate carcinogenesis
por: Cardoso, Marta, et al.
Publicado: (2016)

Structural and functional influences of coagulation factor XIII subunit B heterozygous missense mutants
por: Thomas, Anne, et al.
Publicado: (2015)

Functional Properties of Rare Missense Variants of Human CDH13 Found in Adult Attention Deficit/Hyperactivity Disorder (ADHD) Patients
por: Mavroconstanti, Thegna, et al.
Publicado: (2013)

Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β
por: Asagoshi, Kenjiro, et al.
Publicado: (2012)

Interaction between DNA Polymerase β and BRCA1
por: Masaoka, Aya, et al.
Publicado: (2013)

Metachronous triple primary neoplasms with primary prostate cancer, lung cancer, and colon cancer: A case report
por: Feng, Yuhua, et al.
Publicado: (2018)

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
por: Jamsen, Joonas A., et al.
Publicado: (2021)

Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase β
por: Yoshizawa, Katsuhiko, et al.
Publicado: (2009)

Mutant T4 DNA polymerase for easy cloning and mutagenesis
por: Qi, Ruhu, et al.
Publicado: (2019)

Missense variant in LOXHD1 is associated with canine nonsyndromic hearing loss
por: Hytönen, Marjo K., et al.
Publicado: (2021)

Combinations of deletion and missense variations of the dynein-2 DYNC2LI1 subunit found in skeletal ciliopathies cause ciliary defects
por: Qiu, Hantian, et al.
Publicado: (2022)

Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants
por: Pal, Anasuya, et al.
Publicado: (2023)

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
por: Bratic, Ana, et al.
Publicado: (2015)

Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2
por: Aljarf, Raghad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o520fr595rlrhssn2memi54hs0