Loss of iron triggers PINK1/Parkin-independent mitophagy

In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Ir...

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Detalles Bibliográficos
Autores principales: Allen, George F G, Toth, Rachel, James, John, Ganley, Ian G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981094/
https://www.ncbi.nlm.nih.gov/pubmed/24176932
http://dx.doi.org/10.1038/embor.2013.168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981094/
https://www.ncbi.nlm.nih.gov/pubmed/24176932
http://dx.doi.org/10.1038/embor.2013.168

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