Oversulfated Chondroitin Sulfate Binds to Chemokines and Inhibits Stromal Cell-Derived Factor-1 Mediated Signaling in Activated T Cells

Oversulfated chondroitin sulfate (OSCS), a member of the glycosaminoglycan (GAG) family, was a contaminant in heparin that was linked to the 2008 heparin adverse events in the US. Because of its highly negative charge, OSCS can interact with many components of the contact and immune systems. We have...

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Detalles Bibliográficos
Autores principales: Zhou, Zhao-Hua, Karnaukhova, Elena, Rajabi, Mohsen, Reeder, Kelly, Chen, Trina, Dhawan, Subhash, Kozlowski, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981801/
https://www.ncbi.nlm.nih.gov/pubmed/24718687
http://dx.doi.org/10.1371/journal.pone.0094402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981801/
https://www.ncbi.nlm.nih.gov/pubmed/24718687
http://dx.doi.org/10.1371/journal.pone.0094402

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