Efficacy of Lovastatin on Learning and Memory Deficits Caused by Chronic Intermittent Hypoxia-Hypercapnia: Through Regulation of NR2B-Containing NMDA Receptor-ERK Pathway

BACKGROUND: Chronic intermittent hypoxia-hypercapnia (CIHH) exposure leads to learnning and memory deficits in rats. Overactivation of N-methyl-D-aspartate receptors(NMDARs) can lead to the death of neurons through a process termed excitotoxicity, which is involved in CIHH-induced cognitive deficits...

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Detalles Bibliográficos
Autores principales: Huo, Xin-long, Min, Jing-jing, Pan, Cai-yu, Zhao, Cui-cui, Pan, Lu-lu, Gui, Fei-fei, Jin, Lu, Wang, Xiao-tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981803/
https://www.ncbi.nlm.nih.gov/pubmed/24718106
http://dx.doi.org/10.1371/journal.pone.0094278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981803/
https://www.ncbi.nlm.nih.gov/pubmed/24718106
http://dx.doi.org/10.1371/journal.pone.0094278

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