Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells

The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we fou...

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Detalles Bibliográficos
Autores principales: Xie, Songbo, Chen, Miao, Yan, Bing, He, Xianfei, Chen, Xiwen, Li, Dengwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981814/
https://www.ncbi.nlm.nih.gov/pubmed/24718556
http://dx.doi.org/10.1371/journal.pone.0094496
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author Xie, Songbo
Chen, Miao
Yan, Bing
He, Xianfei
Chen, Xiwen
Li, Dengwen
author_facet Xie, Songbo
Chen, Miao
Yan, Bing
He, Xianfei
Chen, Xiwen
Li, Dengwen
author_sort Xie, Songbo
collection PubMed
description The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders.
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spelling pubmed-39818142014-04-11 Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells Xie, Songbo Chen, Miao Yan, Bing He, Xianfei Chen, Xiwen Li, Dengwen PLoS One Research Article The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders. Public Library of Science 2014-04-09 /pmc/articles/PMC3981814/ /pubmed/24718556 http://dx.doi.org/10.1371/journal.pone.0094496 Text en © 2014 Xie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Xie, Songbo
Chen, Miao
Yan, Bing
He, Xianfei
Chen, Xiwen
Li, Dengwen
Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
title Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
title_full Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
title_fullStr Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
title_full_unstemmed Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
title_short Identification of a Role for the PI3K/AKT/mTOR Signaling Pathway in Innate Immune Cells
title_sort identification of a role for the pi3k/akt/mtor signaling pathway in innate immune cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981814/
https://www.ncbi.nlm.nih.gov/pubmed/24718556
http://dx.doi.org/10.1371/journal.pone.0094496
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