Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity

One mechanism of tumor suppression by pRb is repressing E2F1. Hence, E2f1 deletion diminishes tumorigenesis following Rb1 loss. However, E2F1 promotes both proliferation and apoptosis. It therefore remains unclear how de-repressed E2F1 promotes tumorigenesis. Another mechanism of pRb function is rep...

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Detalles Bibliográficos
Autores principales: Lu, Zhonglei, Bauzon, Frederick, Fu, Hao, Cui, Jinhua, Zhao, Hongling, Nakayama, Keiko, Nakayama, Keiich I., Zhu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982150/
https://www.ncbi.nlm.nih.gov/pubmed/24632684
http://dx.doi.org/10.1038/ncomms4463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982150/
https://www.ncbi.nlm.nih.gov/pubmed/24632684
http://dx.doi.org/10.1038/ncomms4463

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