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Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads
Motivation: Methods for detecting somatic genome rearrangements in tumours using next-generation sequencing are vital in cancer genomics. Available algorithms use one or more sources of evidence, such as read depth, paired-end reads or split reads to predict structural variants. However, the problem...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982158/ https://www.ncbi.nlm.nih.gov/pubmed/24389656 http://dx.doi.org/10.1093/bioinformatics/btt767 |