Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads

Motivation: Methods for detecting somatic genome rearrangements in tumours using next-generation sequencing are vital in cancer genomics. Available algorithms use one or more sources of evidence, such as read depth, paired-end reads or split reads to predict structural variants. However, the problem...

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Detalles Bibliográficos
Autores principales: Schröder, Jan, Hsu, Arthur, Boyle, Samantha E., Macintyre, Geoff, Cmero, Marek, Tothill, Richard W., Johnstone, Ricky W., Shackleton, Mark, Papenfuss, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982158/
https://www.ncbi.nlm.nih.gov/pubmed/24389656
http://dx.doi.org/10.1093/bioinformatics/btt767

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