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Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants

DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and a potential hindrance for cell cycle progression. Cells cope with UV-induced DNA damage through two general strategies to repair the damaged nucleotides and to promote cell cycle progression in the presence of UV-damaged DNA. Defi...

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Detalles Bibliográficos
Autores principales: Wolters, Stefanie, Ermolaeva, Maria A., Bickel, Jeremy S., Fingerhut, Jaclyn M., Khanikar, Jayshree, Chan, Raymond C., Schumacher, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982690/
https://www.ncbi.nlm.nih.gov/pubmed/24424777
http://dx.doi.org/10.1534/genetics.113.158295