Highly Chemoselective Reduction of Amides (Primary, Secondary, Tertiary) to Alcohols using SmI(2)/Amine/H(2)O under Mild Conditions

[Image: see text] Highly chemoselective direct reduction of primary, secondary, and tertiary amides to alcohols using SmI(2)/amine/H(2)O is reported. The reaction proceeds with C–N bond cleavage in the carbinolamine intermediate, shows excellent functional group tolerance, and delivers the alcohol p...

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Detalles Bibliográficos
Autores principales: Szostak, Michal, Spain, Malcolm, Eberhart, Andrew J., Procter, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982934/
https://www.ncbi.nlm.nih.gov/pubmed/24460078
http://dx.doi.org/10.1021/ja412578t

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982934/
https://www.ncbi.nlm.nih.gov/pubmed/24460078
http://dx.doi.org/10.1021/ja412578t

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