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Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain
Human ASH2L is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that Ash2L binds DNA employing a Forkhead-like helix-wing-helix (HWH) domain. In vivo, Ash2L HWH domain is required for binding to the β-globin locus control regio...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983046/ https://www.ncbi.nlm.nih.gov/pubmed/21642971 http://dx.doi.org/10.1038/nsmb.2093 |