Progressive Accumulation of Activated ERK2 within Highly Stable ORF45-Containing Nuclear Complexes Promotes Lytic Gammaherpesvirus Infection

De novo infection with the gammaherpesvirus Rhesus monkey rhadinovirus (RRV), a close homolog of the human oncogenic pathogen, Kaposi's sarcoma-associated herpesvirus (KSHV), led to persistent activation of the MEK/ERK pathway and increasing nuclear accumulation of pERK2 complexed with the RRV...

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Detalles Bibliográficos
Autores principales: Woodson, Evonne N., Anderson, Melissa S., Loftus, Matthew S., Kedes, Dean H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983062/
https://www.ncbi.nlm.nih.gov/pubmed/24722398
http://dx.doi.org/10.1371/journal.ppat.1004066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983062/
https://www.ncbi.nlm.nih.gov/pubmed/24722398
http://dx.doi.org/10.1371/journal.ppat.1004066

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