Inhibiting Na(+)/K(+) ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca(2+) Cycling and Automaticity in Guinea Pig Cardiomyocytes

Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na(+)/K(+) ATPase (NKA), which raises [Na(+)](i) and attenuates Ca(2+) extrusion via the Na(+)/Ca(2+) exchanger (NCX), causing [Ca(2+)](i) elevation. The resulting [Ca(2+)](i) accumulatio...

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Detalles Bibliográficos
Autores principales: Li, Qince, Pogwizd, Steven M., Prabhu, Sumanth D., Zhou, Lufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983106/
https://www.ncbi.nlm.nih.gov/pubmed/24722410
http://dx.doi.org/10.1371/journal.pone.0093928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983106/
https://www.ncbi.nlm.nih.gov/pubmed/24722410
http://dx.doi.org/10.1371/journal.pone.0093928

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