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Inhibiting Na(+)/K(+) ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca(2+) Cycling and Automaticity in Guinea Pig Cardiomyocytes
Cardiac glycosides have been used for the treatment of heart failure because of their capabilities of inhibiting Na(+)/K(+) ATPase (NKA), which raises [Na(+)](i) and attenuates Ca(2+) extrusion via the Na(+)/Ca(2+) exchanger (NCX), causing [Ca(2+)](i) elevation. The resulting [Ca(2+)](i) accumulatio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983106/ https://www.ncbi.nlm.nih.gov/pubmed/24722410 http://dx.doi.org/10.1371/journal.pone.0093928 |