Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. However, the mechanism of ASN-evoked Tau protein m...

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Detalles Bibliográficos
Autores principales: Gąssowska, Magdalena, Czapski, Grzegorz A., Pająk, Beata, Cieślik, Magdalena, Lenkiewicz, Anna M., Adamczyk, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983155/
https://www.ncbi.nlm.nih.gov/pubmed/24722055
http://dx.doi.org/10.1371/journal.pone.0094259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983155/
https://www.ncbi.nlm.nih.gov/pubmed/24722055
http://dx.doi.org/10.1371/journal.pone.0094259

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